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GBR 12783 dihydrochloride

CAS No. 67469-75-4

GBR 12783 dihydrochloride ( GBR12783 2HCl )

Catalog No. M27078 CAS No. 67469-75-4

GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GBR 12783 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
  • Description
    GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.(In Vivo):GBR 12783 (10 mg/kg;?intraperitoneal injection;?for 100 minutes;?male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.
  • Synonyms
    GBR12783 2HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AMPAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    67469-75-4
  • Formula Weight
    485.5
  • Molecular Formula
    C28H34Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.Cl.C(CN1CCN(C\C=C\c2ccccc2)CC1)OC(c1ccccc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.
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