Cart
sales@molnova.com
Home - Products - Others - Other Targets - GBR 12783 dihydrochloride

GBR 12783 dihydrochloride

CAS No. 67469-75-4

GBR 12783 dihydrochloride ( GBR12783 2HCl )

Catalog No. M27078 CAS No. 67469-75-4

GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 69 Get Quote
5MG 110 Get Quote
10MG 160 Get Quote
25MG 267 Get Quote
50MG 408 Get Quote
100MG 590 Get Quote
500MG 1224 Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    GBR 12783 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
  • Description
    GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.(In Vivo):GBR 12783 (10 mg/kg;?intraperitoneal injection;?for 100 minutes;?male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.
  • Synonyms
    GBR12783 2HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AMPAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    67469-75-4
  • Formula Weight
    485.5
  • Molecular Formula
    C28H34Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.Cl.C(CN1CCN(C\C=C\c2ccccc2)CC1)OC(c1ccccc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GRP-60367

    GRP-60367 is the first small molecule rabies virus (RABV) entry inhibitor, which has nanomolar effect on some RABV strains.Grp-60367 inhibits the entry of a subset of the RABV strain.Grp-60367 showed the specificity and effective anti-RABV activity of the scaffold. In the dose-response analysis, the EC50s range from 2 to 52 nM in different host cell lines.

  • NSC-60339

    NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent.

  • Nonapeptide-1

    Nonapeptide-1 can inhibit the synthesis of melanin which makes it of interest for treating certain skin conditions.?

Sign In Join Free